The New Era of Solubility: Noyes-Whitney, AI Predictions & Formulation Trends (2026)
If you are a pharmacy student or a researcher in 2026, the old textbooks aren't telling you the whole story. For decades, we learned that solubility was simple: "Like dissolves like." We memorized the Noyes-Whitney equation, looked at a solubility chart, and mixed powders in a beaker. But today, that approach is obsolete. With 90% of new drug candidates classified as "poorly soluble" (BCS Class II and IV), the industry faces an "insolubility crisis." The modern lab doesn't just "dissolve" drugs; it engineers them. We use Artificial Intelligence to predict solubility limits before a molecule is even synthesized. We use lasers and supercomputers to force "brick dust" molecules into the bloodstream. This article is your guide to the New Science of Solubility . We will decode the modern math, the AI tools like FastSolv , and the breakthrough technologies like Lipid Nanoparticles (LNPs) that are redefining drug delivery in I...